| Pair Name | Corilagin, Fluorouracil | ||
| Phytochemical Name | Corilagin (PubChem CID: 73568 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Corilagin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in S phase | |||
| Gene Regulation | Up-regulation | Expression | CDKN1A | hsa1026 |
| Down-regulation | Expression | CDK2 | hsa1017 | |
| Down-regulation | Expression | HSPA5 | hsa3309 | |
| In Vitro Model | HCT 8 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_2478 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Our results indicate that Corilagin acts as a potentiator of 5-fluorouracil and may have therapeutic potential for patients with CRC. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78. Sci Rep. 2023 Dec 19;13(1):22661. doi: 10.1038/s41598-023-49604-1. | Click |
